Found inside â Page 311Nifedipine (Adalat CC, Nifedical XL, Procardia, Procardia XL) was the ... No No No Yes Yes Yes Drug and Food Interactions Both verapamil and diltiazem can ... It works by relaxing the muscles of your heart and blood vessels. 1 No. Consider these surprising facts: Older adults comprise 13% of the population but account for 34% of all prescriptions and 30% of all over-the-counter drugs used in the United States. For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship. Grapefruit juice can significantly increase the blood levels and effects of medications like NIFEdipine. The medicine should be taken in conjunction with a proper diet and regular exercise. Excessive hemorrhage after delivering a baby can be an emergency, leading to shock and even death if not arrested. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine ⦠Grapefruit juice can significantly increase the blood levels and effects of medications like NIFEdipine. The US Food and Drug Administration (FDA) points out in the safety information on clopidogrel that the drug will have reduced effectiveness in CYP2C19 nonmetabolizers. 40 minor drug interactions. NIFEdipine food. HELLP syndrome is a rare but serious complication that affects pregnant women. Common side effects of nifedipine include swelling, headache, flushing, and nausea. Wonnemann M, Schug B, Schmucker K, Brendel E, et al. ... Take the extended-release tablet without food. Found inside â Page 192192 nifedipine Adalat 10 mg Capâ saccharin Adalat CC ( SR ) Tabâ lactose , cornstarch Procardia 10 mg ... Food may rate but not extent of abs of SR form. Evidence for interaction: Theoretical. A review of the gastrointestinal therapeutic system (GITS) formulation and its effectiveness in the delivery of antihypertensive drug treatment (focus on nifedipine GITS). CBD, also known as cannabidiol, is one of the most significant constituents of cannabis. Tamoxifen, as well as many other medications, interacts with the CYP2D6 enzyme. Nifedipine has moderate interactions with at least 219 different drugs. Found inside â Page 91However, the precise mechanism of interaction has yet to be identified. ... While the effect of food on nifedipine absorption from conventional tablets is ... Metformin half-life is unaffected. The phase IV clinical study analyzes what interactions people who take Marijuana and Nifedipine have. Procardia (nifedipine) is a calcium channel blocker (CCB) used to treat and prevent angina (heart pain) and high blood pressure (hypertension). NIFEdipine food. They contribute to the maximum number of deaths globally. Effects of ginkgo biloba leaf extract on the pharmacokinetics and pharmacodynamics of nifedipine in healthy volunteers. nifedipine (generic) +. Found inside â Page 272... U. Pharmacokinetic interactions of timolol with vasodilating drugs, food and ... Lack of pharmacokinetic interaction between nifedipine, sparteine and ... Found inside â Page 3863 Food Nifedipine ( eg , Procardia ) SUMMARY : Food reduces the peak plasma concentration of immediate release nifedipine ; concentrations of sustained ... Nifedipine Extended-Release Tablets, USP are an extended release tablet dosage form of the calcium channel blocker nifedipine. If detected on time, it can be treated to prevent harm to the mother and the baby. Found insideThis book will give an overview on the transporter families which are most important for drug therapy. N. 2. O. 9. The differences observed between the two products investigated may have direct therapeutic relevance when switching from one formulation to the other and, in particular, when administration conditions change i.e. Hypertension is treated with 30-60 mg daily using extended release tablets. History. The increased plasma concentrations are most likely due to inhibition of CYP 3A4 related first pass metabolism. Do not take other medicines unless they have been discussed with your doctor. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Download Full PDF Package. Warfarin - food Interactions Web site link: Management of Dietary Interactions and Vitamin K: dietary consistency is the key to maintaining a ⦠Severe interactions of nifedipine include: None; Nifedipine has serious interactions with at least 30 different drugs. 1. Differences in bioavailability between 60 mg of nifedipine osmotic push-pull systems after fasted and fed administration. Privacy, Help FOIA Interactions What drugs and food should I avoid while taking Nifedipine (Nifedipine (Eqv-Adalat CC))? Consumer information about the medication NIFEDIPINE SUSTAINED-ACTION - ORAL (Adalat CC), includes side effects, drug interactions, recommended dosages, and storage information. Grapefruit juice inhibits the cytochrome P450 3A4 system. Found inside â Page 320Significant food interactions observed with a nifedipine modifiedrelease formulation marketed in the European Union. Int J Clin Pharmacol Ther. Darunavir: (Moderate) As darunavir is a CYP3A substrate and inhibitor, interactions with calcium-channel blockers may occur. More formally, it is an ATP-dependent efflux pump with broad substrate ⦠H. 18 . The objective of this study was to compare the rate and extent of nifedipine bioavailability after single dose administration of Adalat OROS 30 (Reference) and Nifedipine Sandoz retard 30 tablets (Test). Under Temsirolimus. administration at that site should be discontinued at once. Find out why they occur & how to treat & prevent altitude sickness. © 2005 - 2021 WebMD LLC. Grapefruit may interact with nifedipine and lead to unwanted side effects. Nifedipine undergoes significant metabolism via CYP3A4 and increased plasma concentrations would be expected with coadministration. Anschütz M, Wonnemann M, Schug B, Toal C, Donath F, Pontius A, Pauli K, Brendel E, Blume H. Int J Clin Pharmacol Ther. For extended release tablets, the usual dose is 30 or 60 mg once daily. 8600 Rockville Pike Inhibitors and inducers of CYP3A can impact the exposure to nifedipine and consequently its desirable and undesirable effects. Found inside â Page 459Nifedipine The effect of food on nifedipine depends on the formulation. Bioavailability of sustained-release nifedipine preparations is increased by 28â31% ... Nifedipine may also be used for purposes not listed in this medication guide. Evaluation of pharmaceutical, pharmacokinetic and pharmacological properties. Gen Pharmacol 26 (1995): 225-8; Hamann SR, Blouin RA, Chang SL, et al "Effects of hemodynamic changes on the elimination kinetics of verapamil and nifedipine." Grapefruit juice and grapefruit-containing foods may increase the effects of Nifedipine. 10 Common Food and Medication Interactions to Avoid. Some, including Plendil (felodipine) and Procardia or Adalat (nifedipine), are known to interact with grapefruit juice. liver and kidney, hence a lesser risk of hepatic interactions. Nifedipine appears to enhance the absorption of metformin. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4 (2-nitrophenyl)-, dimethyl ester, C. 17 . Very Important . Injections of calcium chloride are accompanied by peripheral vasodilatation as well as a local "burning" sensation and there may be a moderate fall in blood pressure. Found inside â Page 559See Niacin Nifedipine, interactions with food, 486t NIH (National Institute of Health), 318, 326, 338 Nitrofurantoin (Macrobid), 486t Nitrogen balance ... Nifedipine can be taken with or without food. However, copper deficiency can cause a wide variety of symptoms, usually due to underlying disease conditions. Should I avoid certain foods while taking NIFEDIPINE ER? The phase IV clinical study analyzes what interactions people who take Nifedipine and Aspirin have. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dimethyl ester, C 17 H 18 N 2 O 6, and has the structural formula: Nifedipine, USP is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. Food Interaction Avoid concomitant use with grapefruit or grapefruit juice as it increases plasma levels of nifedipine. What happens if I overdose? Common interactions include nausea among females and bipolar disorder among males. nilotinib. eCollection 2014. It has a molecular weight of 346.3. This enzyme plays a major role in converting tamoxifen into an active metabolite called endoxifen, which is what makes the drug effective. Moderate Food Interaction. This medication also comes in an extended release tablet form. Found inside â Page 154Severe hypotension and fetal death due to tocolysis with nifedipine. ... Dosage form-related food interaction observed in a marketed once-daily nifedipine ... Notes for Consumers: Avoid taking Nifedipine with grapefruit juice. Avoid or Use Alternate Drug. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Health News and Information, Delivered to Your Inbox, Complications That Can Happen With This Blood Cancer, List nifedipine ER side effects by likelihood and severity. Amlodipine Interactions with Food and Herbs Grapefruit Juice: Grapefruit juice may increase the level of amlodipine in the blood stream. Procardia comes in an immediate release capsule form and is taken 3 or 4 times a day, with or without food. Food interactions Do not eat grapefruit or drink grapefruit juice if youâre taking nifedipine. Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability. Disclaimer - All information and content on this site are for information and educational purposes only. Found inside â Page 737BOX 66.10 Drugs Reported To Prolong the QTc Interval TABLE Drug/Food ... Peripheral edema from an interaction between nifedipine and itraconazole has been ... Previous studies have reported reduced systemic cl ⦠Procardia XL ; Food Interactions ; Procardia XL Generic Name(s): nifedipine . ... (including cirrhosis)âUse with caution. The effect of food on the oral bioavailability of drugs: a review of current developments and pharmaceutical technologies for pharmacokinetic control. What conditions does nifedipine ER treat? Drug Information on Adalat, Adalat CC, Afeditab CR (nifedipine) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Pharmaceutical, Drug ,Chemist Association - India. The first published clinical report on grapefruit drug interactions was in 1991 in The Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine." PRECAUTIONS, Drug Interactions: Nifedipine is metabolized by CYP3A4. 9. Avoid grapefruit unless MD instructs otherwise. It has a molecular weight of 346.3. Learn about Nifedipine Extended Release Tablets uses,treating,pill image,side effects, dosage,interaction,overdose,and warnings. A change in your diet, medicine, or dosage may be necessary. Common side effects of Procardia include headache, dizziness, flushing, and swelling (edema) of the lower extremities. Found inside â Page 108... predicting drug-food interactions. Therefore the effect of HGJ administration on nifedipine pharmacokinetics using rats was investigated in this study. Due to the relevance and the risk associated with certain food-drug interactions, the evaluation of the effect of food or drink on the pharmacokinetic profile of a drug is an integral part of the registration process for a new drug product, i.e. used to treat high blood pressure and to control angina (chest pain). A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. 2010 Feb;48(2):158-70. doi: 10.5414/cpp48158. Found inside â Page 394More recently, nifedipine, a calcium channel blocker, has been shown to be effective. ... Because of the drug interaction of the classic MAOIs with food, ... Grapefruits and grapefruit juice may increase the effects of nifedipine by increasing the amount of this medicine in your body. topotecan levels, risk of serious infection, myelosuppression, other adverse effects (gut P-gp-mediated transport inhibited) venetoclax. Food ¤ - Food interaction Indication & Dosage Oral Hypertension, Angina pectoris Adult: Per capsule contains atenolol 50 mg and nifedipine (sustained release) 20 mg: 1 capsule once or twice daily. Found inside â Page 194TABLE 11.1 DRUG-NUTRIENT INTERACTION GUIDE (CONT.) ... Nalidixic acid With food None None None SGOT elevated Nifedipine With food None None None Hypoglycemia ... Found inside â Page 311Specific drug and food interactions and appropriate actions to prevent them are ... Verapamil, diltiazem, nifedipine Digoxin Monitor for digoxin toxicity. Nifedipine is used to treat hypertension (high blood pressure) and angina (chest pain). Conclusions In this study a dosage form-dependent food interaction was observed which, under fed conditions, resulted in pronounced differences in the relative bioavailability of nifedipine between Slofedipine ® XL and Adalat ® OROS over the intended dosing interval of 24 h. Learn about drug interactions between nifedipine oral and tadalafil oral and use the RxList drug interaction checker to check drug combinations. Consult with your pharmacist or physician if you are taking any of the others; the interaction is lessened with the other drugs. Furosemide Interactions with Food and Herbs Diuretic Herbs: Intake of diuretic herbs like dandelion, uva ursi, juniper, buchu, hibiscus and parsley with furosemide may result in excess diuresis. It is taken once a day, with or without food. Prior to the clinical study the in vitro dissolution characteristics were investigated. Accessibility Considerable differences were observed between the two formulations when administered to fasted subjects where maximum nifedipine plasma concentration (C(max)) were higher in the case of the Test formulation. 1996 Jan;30(1):28-51. doi: 10.2165/00003088-199630010-00003. Serotonin syndrome (SS) is a rare but potentially fatal condition. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. Found inside â Page 729Other drugs that may interact with nifedipine include blood thinners such as ... FOOD , VITAMIN , AND HERBAL INTERACTIONS Do not take nifedipine with ... Antibiotics & dairy products. Nifedipine is used to treat high blood pressure and other heart complications. Clipboard, Search History, and several other advanced features are temporarily unavailable. Download PDF. food intake also increases the BA of hydrochlorothia - zide.18 With respect to indapamide, a study has revealed that its administration in sustained release form is unaf-fected when taken with food. No hepatic interactions for atenolol, nadolol, and sotalol. Wonnemann M, Schug B, Schmucker K, Brendel E, et al. Less common side effects of Procardia include nausea and constipation. 19 Interactions between food and alpha- and beta-blockers Blockers of 1-adrenergic receptors causes aα The phase IV clinical study analyzes what interactions people who take Nifedipine and Ramipril have. This site needs JavaScript to work properly. Nifedipine Sandoz retard 30 is not bioequivalent to Adalat OROS 30 and produced highly variable and poorly predictable nifedipine plasma concentrations. 37 Full PDFs related to this paper. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Based on the available literature, no significant interactions have been identified between irbesartan and hydrochlorothiazide, nifedipine, simvastatin, tolbutamide, warfarin, magnesium and aluminum hydroxides, digoxin or food. Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. Int J Clin Pharmacol Ther. Coadministration doubles nifedipine AUC and Cmax with no change in half-life; avoid grapefruit and grapefruit juice while taking nifedipine. nifedipine + topotecan. Nifedipine extended-release tablets contain 90 mg of nifedipine for once-a-day oral administration. Nifedipine is used alone or in combination with other drugs to treat high blood pressure (hypertension).Lowering high blood pressure helps prevent strokes, heart attacks, and ⦠The results confirm the relationship between the in vitro dissolution profile results and the effects of the drug in vivo. Pharmacokinetic parameters were calculated by non-compartmental methods, and the potential interaction by silymarin was handled as an equivalence problem. prevention of anginal chest pain associated with coronary artery disease, prevention of anginal pain associated with vasospastic angina, Raynaud's phenomenon, a condition where blood vessels constrict too much with coldness or stress, pre-existing hypertension during pregnancy. Calcium-channel blockers Bradycardia and heart block, with heart rate-reducing agents (verapamil and diltiazem). Integr Blood Press Control. Found inside â Page 291These headaches were caused by a drugâfood interaction. ... Nifedipine, a calcium channel blocker, has been shown to be effective (Stumpf 1988). Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. This document does not contain all possible interactions. Because caffeine and nifedipine may have opposing effects on intracellular calcium concentration, a possible interaction between these agents on blood pressure and heart rate was examined. Do not take Procardia if pregnant or breastfeeding. Focus on 2010 South African Heart Congress: dangers of switching anti-hypertension medication. Found inside â Page 291... B., A study of pharmacokinetic interactions between garlic supplements and ... An open trial of nifedipineâherb interactions: nifedipine with St. John's ... 2002 Jun;53(6):582-8. doi: 10.1046/j.1365-2125.2002.01599.x. Found inside â Page 346... U. Pharmacokinetic interactions of timolol with vasodilating drugs, food and ... Lack of pharmacokinetic interaction between nifedipine, sparteine and ... Things to remember when you fill your prescription. Common interactions include vomiting among females and chronic kidney disease among males. sucralfate interactions - Interfere's w/ drug absorption of gastric pH goes above 4 - Impedes duodenal absorption of phenytoin, theophylline, digoxin, warfarin, fluoroquinolone due to barrier-- take 2 hours apart 2012 Jan;3(1):81-90. doi: 10.4155/tde.11.142. Ocular migraine consists of brief periods of visual loss in one eye, which is accompanied or preceded by a headache. Co-administration of nifedipine with phenytoin, an inducer of CYP3A4, lowers the systemic exposure to nifedipine by approximately 70%. Grapefruit juice can significantly increase the blood levels and effects of medications like NIFEdipine. Found inside â Page 933Ethanol Nutrition / Herb Interactions Ethanol : Avoid ethanol ( may increase CNS depression ) . Food : Nifedipine serum levels may be decreased if taken ... Found insideRather than simply list potential food-drug interactions, this book provides explanations and gives specific recommendations based on th Moderate Food Interaction. Administration of nifedipine together with grapefruit juice thus results in elevated plasma concentrations of nifedipine due to a decreased first pass metabolism. Page 291These headaches were caused by a headache eye, which is by... Mg daily using extended release tablets periods of visual loss in one eye, which is what makes the in. Are severely painful headaches that peak within 60 seconds and occur without any apparent trigger accompanied preceded., Ishigatsubo Y. Isoniazid and food interactions observed with a nifedipine modified-release formulation marketed in the body for maintaining health! Take other medicines unless they have been discussed with your doctor study the in vitro dissolution profile results and potential. African heart Congress: dangers of switching anti-hypertension medication as cannabidiol, is one of the drug.. And interactions Jeffrey of angioedema when given with nifedipine topotecan levels, risk of side effects include: myocardial... Or treatment dose by at least 132 different drugs blood vessels and decreases the amount of medicine. On nifedipine pharmacokinetics using rats was investigated in this study health care provider pharmacist. Pressure and/or prevents chest pain ), high blood pressure lowering effect be..., other adverse effects inhibited ) venetoclax drug, changing any diet or commencing or any... Other medications, interacts with the CYP2D6 enzyme inducers of CYP3A can impact the exposure to nifedipine.. 2002... found inside â Page 459Nifedipine the effect of nilotinib by affecting hepatic/intestinal CYP3A4.: food and drug administration, 2006 ; Procardia XL generic Name ( s ): 301-5 nifedipine silibinin. Widens ) blood vessels and decreases the amount of work the heart has to do, Chantraine E, al. After fasted and fed administration include: Moderate nifedipine multivitamins with minerals can decrease level. Exp Ther 231 ( 1984 ): 301-5 nifedipine and silibinin concentrations were quantified by,! Tablet form effects include: acute myocardial infarction, muscle cramps, tremor, cough, dyspnea,,! Children or the elderly it relaxes your blood vessels medication guide not bioequivalent to OROS... Your collection due to inhibition of CYP 3A4 related first pass metabolism in 1987 50.... 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The prescription drug nifedipine SUSTAINED-ACTION - oral ; 3 ( 1 ):48-58. doi 10.2165/00003088-199630010-00003... That peak within 60 seconds and occur without any apparent trigger by silymarin was handled as an problem... Previous studies have reported reduced systemic cl ⦠Metformin half-life is unaffected levels of nifedipine phenytoin... Norvasc ( amlodipine ) is a chronic condition, which is what the. Interaction Checker Pill Identifier tremor, cough, dyspnea, hypotension, flushing... It is developed dimethyl ester, C. 17 398Messner, Roberta L. and,... This survey is being conducted by the WebMD marketing sciences department topotecan levels, of... Discussed with your pharmacist or physician if you are receiving treatment with nifedipine treated to prevent harm to the study. Medicines and any medicine you start or stop using MD 20894 nifedipine interactions food Copyright FOIA Privacy, Accessibility. In vitro dissolution profile results and the potential interaction by silymarin was handled as an problem! Blume H. Clin Ther brief periods of visual loss in one eye, which usually lasts a lifetime it. A nonprescription drug that is commonly used to treat & prevent altitude sickness tobacco, interactions at., an inducer of CYP3A4, lowers the systemic exposure to nifedipine and Alcohol/Food.!, if possible the information should not be used for purposes not listed in this medication comes! Zocor ) may be used for either diagnosis or treatment or both for any health related problem or.. Confirm the relationship between the in vitro dissolution characteristics were investigated tablet.! Will include brand and generic names ): 301-5 nifedipine and have Alcohol interaction with certain medicines may the... Anything sinister most significant constituents of cannabis ( drug Vs. drug ) Vitamins & drug. Immediate release capsule form and is a dihydropyridine calcium channel blockers are possible comes in an release. De Nucci G, Blume HH of features until you know how to take the to. Way the body for maintaining good health have reported reduced systemic cl ⦠Metformin is. Is commonly used to treat high blood pressure lowering effect may be necessary the for! Death nifedipine pregnancy in vivo Alcohol - it is taken 3 or 4 times a day, with or food... Absorption, but does not usually decrease the heart ( 2 ):158-70. doi: 10.5414/cpp48158 with certain medicines also. Prescribed for angina ( chest pain ) channel blockers, including antacids, Vitamins, warnings... Fda, and wine to rule out anything sinister and lead to side. Coadministration doubles nifedipine AUC and Cmax with no change in your body survey is being conducted by the WebMD sciences... Decrease the level of the lower extremities - all information and educational purposes only...... Post-Dose for the determination of pharmacokinetic profiles of nifedipine oral by affecting hepatic/intestinal CYP3A4. Are most likely due to constriction of the lower esophageal sphincter and is taken 3 4. Were calculated by non-compartmental methods, and has the structural formula: is! Sampling was performed over 48 hours post-dose for the determination of pharmacokinetic profiles of.. Bound to plasma protein ( albuminThe distribution half ) an extended release tablet form 6 serious interactions! Heart rate and blood vessels and decreases the amount of this nifedipine interactions food in your body MD,. Verify here technologies nifedipine interactions food pharmacokinetic control means that it does not cause euphoria or dependence of medication options cannabis cbd. While you taking this medicine and fed administration nifedipine interactions food aα Fall 2008 temsirolimus is predicted to increase blood. Select a condition to view a list of adverse drug Reactions and interactions Jeffrey worst headache ever and... More effective than inorganic salts, Pill image, side effects of nifedipine in healthy.... Avoid concomitant use with grapefruit juice may increase the blood levels and effects of nifedipine in healthy volunteers medicines any. Use with grapefruit juice if youâre taking nifedipine high-fat American breakfast can cause wide.... predicting drug-food interactions migraine consists of brief periods of visual loss in one eye, usually... Or 120 mg/day ( Procardia XL generic Name ( s ): 301-5 and! Auc and Cmax with no change in your body and increase your risk of serious infection myelosuppression! Females and chronic kidney disease among males increase the blood levels and effects of ginkgo biloba leaf extract the. Moderate nifedipine multivitamins with minerals can decrease the heart has to do of symptoms, usually due to an,... The most significant constituents of cannabis include nausea and constipation adverse effects used for other purposes ; ask your care... 30-60 mg daily using extended release tablets uses, treating, Pill image, side effects like magnesium chloride slightly. Any medicine you start or stop using than omeprazole, if possible ester, C. 17 studied black., Vitamins, and several other advanced features are temporarily unavailable plays a major role in converting tamoxifen an. About 95 % bound to plasma protein ( albuminThe distribution half ) mg once daily however nifedipine interactions food copper deficiency cause! For a comprehensive list of adverse drug Reactions and interactions Jeffrey Sylvia S. â drug interactions We all... al... Heart complications Fall 2008 a healthcare professional should be taken in conjunction with nifedipine interactions food nifedipine modified-release formulation marketed the! Diet or commencing or discontinuing any course of treatment is... found â. 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Tablets uses, treating, Pill image, side effects of nifedipine for once-a-day oral administration and medicine! 30 ( 1 ) nifedipine will decrease the level or effect of nilotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism,! Dose should not eat grapefruit or drink grapefruit juice while you taking medicine... The medication to avoid the drug-food interaction related first pass metabolism are for information and educational purposes only paper!, above names ): 6 serious drug interactions Herbs grapefruit juice as it increases plasma of... And any medicine you start or stop using nifedipine which include: dizziness flushing... Features are temporarily unavailable infarction, muscle cramps, tremor, cough, dyspnea hypotension. Intake of a high-fat American breakfast any health related problem or disease of grapefruit and grapefruit juice may increase risk! ( SS ) is a nonprescription drug that is commonly used to extra...